Pharmacogenetics of nonsteroidal anti-inflammatory drugs
نویسندگان
چکیده
منابع مشابه
Nonsteroidal anti-inflammatory drugs.
Non-steroidal anti-inflammatory drugs (NSAIDs) are usually defined as those agents that inhibit one or more reactions involved in the production of prostaglandins and thromboxanes, important mediators of the inflammatory process in many organs and tissues. They find use in horses in the supportive treatment of a variety of systemic states and painful musculoskeletal or soft tissue conditions. T...
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It is important for orthopaedic surgeons to understand the role of prostaglandins in bone physiology and the mechanism of action of nonsteroidal anti-inflammatory drugs and their role in fracture healing, fusion, osteointegration, and aseptic loosening. Nonsteroidal anti-inflammatory drugs have benefits and risks in orthopaedic use, and their effects should be considered.
متن کاملNonsteroidal Anti-Inflammatory Drugs and the Kidney
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the isoenzymes COX-1 and COX-2 of cyclooxygenase (COX). Renal side effects (e.g., kidney function, fluid and urinary electrolyte excretion) vary with the extent of COX-2-COX-1 selectivity and the administered dose of these compounds. While young healthy subjects will rarely experience adverse renal effects with the use of NSAIDs, elderly pa...
متن کاملNonsteroidal anti-inflammatory drugs: cyclooxygenase 2 inhibitors.
OBJECTIVES To analyze selective COX 2 inhibitor nonsteroidal anti-inflammatory drugs (NSAID) in terms of their mechanism of action, principal indications, posology and most common adverse effects. SOURCES MEDLINE and LILACS databases and Food and Drug Administration (FDA) and National Agency for Sanitary Vigilance (ANVISA - Agência Nacional de Vigilância Sanitária) websites. The most importan...
متن کاملVigilance in Prescribing Nonsteroidal Anti-inflammatory Drugs
To the Editor: We read with great interest the article entitled, “A Case of Acute Myocardial Infarction Induced by Selective Cyclooxygenase-2 Inhibitor” by Seo et al.[1] The authors have shown a correlation of aceclofenac intake with the myocardial infarction. This is really important information to be noted as aceclofenac or any nonsteroidal anti-inflammatory drugs (NSAIDS) of this group were ...
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ژورنال
عنوان ژورنال: The Pharmacogenomics Journal
سال: 2012
ISSN: 1470-269X,1473-1150
DOI: 10.1038/tpj.2012.40